dREG Gateway

Welcome to dREG gateway!

Find the location of enhancers and promoters using PRO-seq, GRO-seq, and ChRO-seq data.

The gateway status and updates are here!


How does it work?

The dREG gateway predicts the location of enhancers and promoters using PRO-seq, GRO-seq, or ChRO-seq data. The server takes as input bigWig files provided by the user, which represent PRO-seq signal on the plus and minus strand. The gateway uses pre-trained dREG and dREG-HD models to identify divergent transcript start sites and impute the predicted DNase-1 hypersensitivity signal across the genome. The dREG gateway uses pre-trained models that work in any mammalian organism (other organisms coming soon).

dREG Gateway

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How is it used?

Registered users need only upload experimental data in the required format and push the start button. Once the job is finished, the user will be notified by e-mail. Results can be downloaded to the user’s local machine, or viewed in the Genome Browser via the handy trackhub link.

Click this link to check how to prepare your PRO-seq, GRO-seq, or ChRO-seq data in bigWig format.

See our FAQ for additional questions.

dREG model

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Publications

dREG model

Danko, C. G., Hyland, S. L., Core, L. J., Martins, A. L., Waters, C. T., Lee, H. W., ... & Siepel, A. (2015). Identification of active transcriptional regulatory elements from GRO-seq data. Nature methods, 12(5), 433-438.